Abstract
A novel series of substituted (E)-3-(Benzo [d]thiazol-2-ylamino)phenylprop-2-en-1-onewere synthesized starting from 2-aminobenzothiazole and 1-aryl-3,3-bis- (methylsulfanyl)-2-propen-1-onesin the presence of a catalytic amount of sodium hydride in THF. The synthesised compounds' structures were confirmed by IR, Mass spectrometry, (1)H NMR, (13)C NMR and HRMS spectral data. These compounds were evaluated for their antidiabetic activity, and most of the derivatives of (E)-3-(Benzo [d]thiazol-2-ylamino)phenylprop-2-en-1-one displayed significant antidiabetic activity.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amylases / antagonists & inhibitors
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Animals
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Benzothiazoles / chemical synthesis
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Benzothiazoles / chemistry
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Benzothiazoles / pharmacology
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Crystallography, X-Ray
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Enzyme Activation / drug effects
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Glucosidases / antagonists & inhibitors
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Hypoglycemic Agents* / chemical synthesis
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Hypoglycemic Agents* / chemistry
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Hypoglycemic Agents* / pharmacology
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Propiophenones / chemical synthesis
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Propiophenones / chemistry
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Propiophenones / pharmacology
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Swine
Substances
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Benzothiazoles
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Hypoglycemic Agents
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Propiophenones
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Amylases
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Glucosidases